Tumor Susceptibility Gene 101 (TSG101) (N-Term) Peptide
TSG101
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN2183454
Aperçu rapide pour Tumor Susceptibility Gene 101 (TSG101) (N-Term) Peptide (ABIN2183454)
Antigène
TSG101
(Tumor Susceptibility Gene 101 (TSG101))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Séquence
- YKYRDLTVRE TVNVITLYKD LKPVLDSYVF NDGSSRELMN LTGTIPVPYR
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-TSG101 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeat freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TSG101 (Tumor Susceptibility Gene 101 (TSG101))
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Sujet
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The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
Alias Symbols: TSG10, VPS23
Protein Size: 390 -
Poids moléculaire
- 44 kDa
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ID gène
- 7251
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NCBI Accession
- NM_006292, NP_006283
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UniProt
- Q99816
Antigène
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